I recently upgraded my Mac to OS 10.6 and I had to rebuild Qt and PyQt to get them working again. I installed Qt 4.5.3 from source and then installed sip 4.9.1 and PyQt4.6.1. Immediately it failed to work with the following error:

>>> from PyQt4 import QtCore
Traceback (most recent call last):
  File "", line 1, in 
ImportError: dlopen(/Library/Python/2.6/site-packages/PyQt4/QtCore.so, 2): Symbol not found: _sipQtConnect
  Referenced from: /Library/Python/2.6/site-packages/PyQt4/QtCore.so
  Expected in: flat namespace
 in /Library/Python/2.6/site-packages/PyQt4/QtCore.so

Some quick searching led me to this post, which implied that hacking PyQt’s configure.py file to force the architecture to be 64-bit would do the trick.
So where it says:

for a in sipcfg.arch.split():
    if a == 'i386':
    elif a == 'x86_64':
    elif a == 'ppc':

Replace qmake_archs.append('x86') with qmake_archs.append('x86_64').
Now PyQt works again.

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